Who Are We?
Behavior Analysis + Neuroscience
Dr. Beatrice Barrett and Dr. Ogden Lindsley
The Beatrice Barrett Behavior Analytic Neuroscience Initiative at the University of North Texas supports two behavioral neuroscience labs within the Department of Behavior Analysis.
Our mission is to use behavior analytic concepts and free-operant methods to advance the understanding of operant behavior as it relates to neural activity.
This is accomplished through research, education, and dissemination. This initiative is maintained through an endowment made by Dr. Beatrice H. Barrett, whose vision for the future of behavior analysis included the domain of neuroscience.
This site hosts Dr. Barrett’s electronic archive featuring her publications, data, and institutional records from her Behavioral Prosthesis Laboratory at the Fernald State School in Waltham, MA, as well as pages highlighting the on-going research of the Barrett Initiative labs in the Behavior Analysis Department at the University of North Texas, and promoting virtual and in-person events connecting behavior analytic and neuroscientific research.
Suggested Readings To Get Started in Behavior Analytic Neuroscience:
News and Updates From the Barrett Initiative Blog…
Want to learn how behavior analysis and neuroscience? Dr. Donahoe’s writing is an excellent place to begin.
As we get ready for our upcoming virtual events with Dr. John Donahoe, we wanted to share some readings we return to often in our Barrett Initiative lab meetings. 1. A Recent Chapter on Biological Behaviorism Dr. Donahoe recently contributed a chapter on biological...
Dr. Beatrice Barrett’s Legacy
Her research spanned many critical areas in Behavior Analysis, looking at response discrimination and differentiation, reinforcer assessment, programmed instruction, classroom adjustment of children with developmental disabilities, behavioral dimensions of trainability (functional assessments of children with severe and profound disabilities), as well as staff and teacher training. Dr. Barrett and her colleagues were among the first to apply free-operant behavioral principles to the teaching of those with developmental disabilities. Towards the end of her career, she worked towards creating a measurement system for children with developmental disabilities so their quality of life would be improved.
Research
Research conducted by the Barrett Initiative investigates links between operant behavior and neural activity, both by using methodology and measurement approaches developed by Dr. Barrett and by Dr. Ogden Lindsley and by developing new methods of analysis
Neuro-Behavioral EEG Laboratory
Dr. Daniele Ortu
Primary Investigator
Daniele Ortu is a Research Assistant Professor in the Department of Behavior Analysis at the University of North Texas, where he teaches Behavioral Neuroscience. He received his M.A. from AILUN in Nuoro (Italy) and his Ph.D. from the University of Stirling (United Kingdom). His primary interests are real-time measures of brain activity, specifically Electroencephalography and Event-Related Potentials and how they relate to a Skinnerian perspective. Conceptually, Dr. Ortu is involved in understanding how brain responses can help provide some missing pieces of the puzzle when it comes to comprehending complex human behavior. Daniele is on the editorial board of the Journal for the Experimental Analysis of Behavior, Behavior and Social Issues, Behavior and Philosophy, and is a Guest Editor for Frontiers in Human Neuroscience.
Neuroplasticity and Repertoire Repair Lab
Dr. April Becker
Primary Investigator
April Becker is an Assistant Professor in the Department of Behavior Analysis at the University of North Texas. She received her B.S. from Colorado State University, where she studied cellular mechanisms of muscle atrophy under Dr. Donald Mykles and behavioral ecology and songbird vocalizations under Dr. Myron Baker. After working in various zoos and aquariums as an animal trainer, presenter, and caretaker, she earned her M.S. in Behavior Analysis from the University of North Texas working with Dr. Jesús Rosales-Ruiz and Dr. Sigrid Glenn studying motivation, creativity and cultural contingencies. Dr. Becker earned her Ph.D. in Biomedical Neuroscience from the University of Texas Southwestern Medical Center where her work with Dr. Mark Goldberg focused on behavioral recovery from brain injury and the use of plasticity-modulating pathways to augment rehabilitation. Dr. Becker’s research and interests have several aims: to understand multi-level selection ranging from brain to cultural development, to better understand the basic brain mechanisms of learning and behavior in a radical behavior framework, and to develop better clinical and translational approaches to brain injury rehabilitation.
Education
Interested in Educational Opportunities with the Barrett Initiative and the Behavior Analysis program at the University of North Texas?
Current Interdisciplinary Courses Offered:
Behavioral Neuroscience - BEHV 5900
The brain plays a fundamental role in allowing organisms to learn and interact effectively with their environment. In this course we will analyze how neural activation and anatomy are shaped – during the lifetime of the individual – by relevant behavioral variables. We will look at different levels of resolution, starting from the individual neuron, its structure and how neurons communicate with each other, to larger structural elements (e.g., the hippocampus), and to the whole organism. In all cases we will take into account how experience continuously modifies structure and activation of neural variables. The course will stress that brain activation in relation to behavioral variables can only be understood by taking a systemic approach in which the role of individual areas is best understood within the context of other brain areas and within the natural environment. We will introduce the methodologies typically used in behavioral neuroscience, with a specific focus on neuroimaging technologies applied to the behaving organism.
Brain Plasticity and Behavioral Dynamics - BEHV 5910
In the first part of this course, students will be introduced to prerequisite concepts in biology and behavioral sciences necessary to understand brain function. They will then broadly survey the general architecture of the mammalian brain, the known functions of important areas, the integration of substructures, and to a few important general principles of mammalian connectivity and network structure. The second part of the course will focus on the mechanisms by which brains change on the cellular, synaptic, and systems levels, the relationship between brain and behavioral changes, the relationship of plasticity to the environment, and the physiological mediation of environment-behavior relations. Although it is not required, students will be best prepared for this course if they have already taken one at least one of the following: BEHV4900-711 (Behavioral Neuroscience), BIOL 4751/BIOL 5751 (Neuroscience: Cells and Circuits), and BEHV 2700, 2300, 3150, or 5100 (Introduction to Behavior Analysis).
To further research and training missions of the Initiative, both the Neurobehavioral EEG Lab and the Neuroplasticity and Repertoire Repair Lab provide advanced research training and opportunities on the undergraduate, master’s, doctoral, and postdoctoral levels. These opportunities are designed to provide well-rounded experiences and development for young scientists that will eventually contribute to the intersection of behavior analysis and neuroscience through independent research or clinical practice.
Both laboratories participate in the Masters of Science Training Program as well as UNT’s Doctoral program in Health Sciences Research with a concentration in Behavior Analysis. Students training in UNT’s Behavior Analysis undergraduate program, as well as Biology, Psychology, or other relevant majors, are welcome to seek undergraduate research experience. Both labs have hosted McNair Undergraduate Scholars as well as Undergraduate Research Fellows.
Potential postdoctoral trainees are invited to inquire with the PIs Dr. Daniele Ortu or Dr. April Becker or the Director Dr. Jesus Rosales-Ruiz about potential openings.
Dissemination
The Barrett Initiative works to disseminate information within the behavior analysis community, the neuroscience community, and the scientific community at large that to advance the understanding of the connections between operant behavior and neural activity. In addition to publications, the Barrett Institute hosts a range of virtual and live events featuring researchers from both neuroscience, behavior analysis, and other complimentary disciplines.
Beatrice H. Barrett Lectures on Brain and Behavior: Paradigm Fusion
We’re hard at work planning events to bring together professionals from across the neurosciences and behavior analysis. Stay tuned for more details about virtual and live events. We’re thrilled to announce our next speaker, Dr. Michael Kilgard. More details will be released soon.
Upcoming for Fall 2024:
Biography
Abstract: Translational Research and Reproducibility in Neurological and Psychiatric Behavioral Application- October 15th, 2024
Neuroscience has not to date produced significant treatments for people with neurological and psychiatric conditions. This talk will review the processes through which scientific discovery leads to new clinical therapies related to behavior, summarize the primary reasons why initial excitement often fails to translate to clinical utility, and explore the lessons learned about how to improve the robustness of scientific study and improve clinical application.
Abstract: Vagus Nerve Stimulation (VNS) during Therapy Promotes Synaptic Plasticity and Enhances Recovery after Neurotrauma- November 1st, 2024
This talk will review the science behind a promising new therapy to restore function after neurotrauma. The technique uses brief bursts of closed-loop vagus nerve stimulation (VNS) to engage pro-plasticity neuromodulatory circuits during therapy. VNS during therapy was first developed in rats ten years ago by researchers at the Texas Biomedical Device Center (www.txbdc.com) and has now been tested in over two hundred implanted patients.
In August of 2021, the therapy was approved by the U.S. FDA to treat arm impairments in people with chronic ischemic stroke. Our ongoing animal studies demonstrate that VNS paired with rehabilitative training enhances recovery in multiple models of neurological injury, including spinal cord injury, stroke, TBI, and PTSD. Recovery is produced by synaptic plasticity in spared neural networks activated during therapy.
Now that the synaptic mechanisms responsible for targeted plasticity therapy are well understood, the TxBDC has shifted its focus to developing the hardware and software tools necessary to deliver VNS-enhanced therapy for the most debilitating neurological and psychiatric conditions. Results from our clinical trials in people with chronic PTSD, stroke and spinal cord injury are encouraging.
The talk will conclude by discussing lessons for improving the plasticity by other forms of therapy.